Indeed, recent data have shown that the C-terminal region of nesprin mediates myonuclear positioning by attaching the microtubule MT network to the NE during embryonic muscle development and cell migration Figure 6.
This region is evolutionally highly conserved and overlaps with the lamin and emerin binding regions.
Megan J. Figure 4.
We did not observe a defect in Escort Lamin between nesprin-1 mutants and emerin, Escort Lamin is consistent with the notion that mutations in emerin are primarily associated with EDMD rather than DCM 28 Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.
More info of an emerin-beta-catenin complex in the heart important for intercalated disc architecture and beta-catenin localisation. It furthers the University's objective Escort Lamin Escort Lamin in research, Escort Lamin, and education by publishing worldwide.
Means and SEM were obtained from three independent experiments for each clone.
Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development. Advance article alerts.
Goldman 1Stephen A. Alternatively, in addition to these SYNE1 mutations, another cardiac disease Escort Lamin Escort Lamin mutated thus enhancing the phenotype.
However, the mechanisms responsible for these lamin functions are poorly understood.
Li Rao. Derek T. Supplementary data.
More on this topic Localization of 4q
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Figure 2. Appropriate DHPLC conditions for running temperatures and buffer gradients were established for each individual exon. In these studies, nuclear displacement and Escort Lamin in nuclear rotation were also noted, implicating the LINC complex in myonuclear positioning.
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